Novel protein biomarkers in prostate cancer identified

15th February 2016

Posted By Paul Boughton

Protagen AG has announced the identification of novel protein biomarkers in prostate cancer, which are potential drug targets supporting novel strategies in precision medicine.

Using the proprietary Protagen SeroTag technology, the discovery was made in collaboration with Professor Helmut Klocker, Medical University of Innsbruck and Oncotyrol Center for Personalized Cancer Medicine, Innsbruck, and Professor Mark Rubin, Cornell University and Targos Molecular Pathology GmbH, Kassel.

Measuring serum autoantibodies in a liquid biopsy of prostate cancer patients, the team was able to successfully confirm tissue specific biomarkers via immunohistochemistry.

Professor Klocker stated: “This is a novel route to new and more specific biomarkers to allow for better detection of prostate cancer inflammation. In co-operation with Protagen, we were not only able to identify new relevant prostate specific autoantigens, eg SPOP, SPAST, STX 18, but also show the orthogonal validation of this serum marker on tissue microarrays with our partners at Targos.” 

Professor Rubin: ”We’ve been working on the role of SPOP and its mutations in prostate cancer for quite some time, it is really exciting to learn more about the links to the immune system and the appearance of SPOP specific autoantibodies in patient sera.”

“It is always a good cross validation, when two independent methods yield the same result. Validated biomarkers in immune oncology and other immune diseases are a valuable asset. We are very excited to work with Protagen together in this emerging field,” commented Dr Thomas Henkel, CEO of Targos. 





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