Beyond flat biology: new 3d printing material

Nanoscribe has launched its new IP-Visio printing material for life science applications. This material is non-cytotoxic, low-fluorescent and designed for the 3D microfabrication of biocompatible microstructures. With IP-Visio, Nanoscribe’s 3D printers open up the way to produce intricate, filigree microenvironments needed in 3D cell culture and tissue engineering.

2D cell culture systems have been standard for the past century, enabling findings in many applications, ranging from stem cell research, drug screening and regenerative medicine. However, cells interact with neighbouring cells, the extracellular matrix, and surrounding molecules in 3D. Cells in vivo experience an extremely complex three-dimensional environment at the organ, tissue and cellular level down and below the micrometre scale. The advances of Nanoscribe’s 3D Microfabrication have demonstrated how this technology enables the fabrication of intricate 3D microstructures such as 3D cell scaffolds. Now the company takes a further step forward and presents IP-Visio, the new printing material designed for the fabrication of biocompatible 3D microstructures.

The printing material is non-cytotoxic according to ISO 10993-5. This makes it suitable for cell-friendly 3D scaffolds. With this material, high-precision microstructures can be fabricated to mimic realistic and high-precision microenvironments. An exemplary application is multi-cell scaffolds that serve as supporting material to seed and study cells in 3D.

Moreover, IP-Visio shows a very low autofluorescence. This property allows a clear view through the printed scaffolds. Scientists can analyse cellular components and processes by means of fluorescence microscopy without interference of the printed structures.

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