The yeast two-hybrid system has become an increasingly important tool to identify and map novel protein-protein interactions.
Yet, many researchers do not wish to burden themselves with setting up a yeast facility and working out the intricacies of yeast two-hybrid screening.
Here, Dualsystems Biotech offers a solution: custom yeast two-hybrid screens only require the researcher to supply a bait to be screened and to choose a cDNA library of interest. Bait construction, expression tests, pilot screens and ultimately, screening of the cDNA library and subsequent analysis of the interactors is carried out by us. Within 34 months the customer will receive the results of a complete yeasttwo-hybrid screen, including sequences and plasmids of all interactors.
For researchers working with proteins that are unsuitable for yeast two-hybrid screens, such as integral membrane proteins or membrane-associated proteins, Dualsystems offers another solution: our proprietary DUALmembrane system can be used to screen such proteins for novel interaction partners.
The advantages are obvious:full-length proteins can be screened and interactions are detected in their natural setting, the membrane. The DUALmembrane system is offered both as a custom service and as a kit containing all necessary plasmids and strains to carry out a DUALmembrane screen in your lab.
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Dualsystems Biotech AG is based in Zürich, Switzerland. www.dualsystems.com
