In other words, the researchers found a new signaling pathway that charters the course for cell progression to allow their growth. The team made an intriguing connection between nerve cells and a receptor called DCC (Deleted in Colorectal Carcinoma). The discovery means cells perform functions in unimagined ways – challenging previous views on how cells respond to their environment – that could prove beneficial in cell growth following nerve damage or detrimental in diseases such as cancer.
"We found an alternate way that helps nerve cells respond quickly and locally," says co-author Philippe P. Roux, a professor of pathology and cell biology and a researcher at the University of Montreal Institute for Research in Immunology and Cancer (IRIC). "This is just the beginning, since our findings suggest that more cellular receptors may function in the same way."
Dr. Roux, who is also Canada Research Chair in Signal Transduction and Proteomics, says the study could potentially open new treatment avenues: "We can envisage manipulating this alternate mechanism to make cells respond locally to their environment. Our findings mean that scientists must consider a new way that cells organise themselves to perform essential functions."