Provider of life science solutions Creative Biolabs recently announced the introduction of innovative technological advancement in single-chain variable fragment (scFv) generation. The technology promises to significantly advance Chimeric Antigen Receptor T cell (CAR-T) therapy.
CAR-T therapy has garnered growing attention in cancer treatments, largely due to its innovative approach. At its core, the therapy utilises chimeric antigen receptors (CARs) to guide T cells toward identifying unique antigens found in cancer cells. scFv is a critical component of CAR, providing the specificity required for targeted cancer cell recognition and elimination. The specificity and efficacy of CAR-T cell therapy largely depends on the selection of the scFv. The ideal scFv should bind to an antigen that is highly expressed on cancer cells but has limited or no expression on normal cells to minimise off-target effects and reduce the risk of harming healthy tissues.
Creative Biolabs aims to break new ground in the scFv generation using their proprietary technology. The technology outshines conventional methods by producing scFv with superior affinity and specificity. The improved scFv not only enables precise targeting of cancer cells but also enhances T cell activation, leading to more effective destruction of tumors.
A scientist specialising in CAR-T therapy research said of the company: "Creative Biolabs provides an array of scFv generation strategies, offering us tailored solutions. Their high-affinity, premium-grade scFvs, help our research endeavors significantly."
Furthermore, Creative Biolabs extends comprehensive services encompassing CAR design & construction, empowering researchers in their preclinical development efforts. With expertise in CAR engineering, their team customizes CAR constructs to optimise T-cell functionality while mitigating off-target effects, ensuring efficacy and safety in research applications.
The integration of Creative Biolabs' superior scFv generation technology into CAR cell design amplifies the therapeutic potential of CAR-T therapy, paving the way for more effective cancer treatment development.
