New culture medium

Thermo Fisher Scientific has launched the Gibco OncoPro Tumoroid Culture Medium Kit, the first culture medium specifically developed for the expansion of patient-derived tumoroids, or cancer organoids, from multiple cancer indications.

While cancer remains a leading cause of death globally ,hurdles remain in bringing new cancer therapies to patients, with up to 97% of drug candidates failing in clinical trials. More closely resembling donor tissue than traditional 2D cell models, patient-derived tumoroids – cultures of tumor cells derived from individual patients – hold promise in helping improve clinical trial success rates by enabling researchers to better model disease and predict patient response to therapeutics in vitro. Yet use of tumoroids in cancer research has been limited due to challenging culture requirements and a lack of commercially available media systems. Thermo Fisher’s new off-the-shelf, modular tumoroid culture medium kit is designed to make complex cancer models more accessible to researchers.

“Cancer’s unpredictable nature presents a significant scientific and clinical challenge for future discoveries and in delivering life-saving treatments to patients,” said Brian Douglass, vice president and general manager, cell biology at Thermo Fisher Scientific. “Globally, millions of patients and their families still await a cure for cancer despite the decades of advances in research, diagnostics and treatments aimed at helping lower cancer mortality. We developed the new OncoPro Tumoroid Culture Medium Kit so the scientific community can take greater advantage of tumoroid models to help bring drug candidates to market faster and more cost-effectively.”

Thermo Fisher is dedicated to supporting scientists as they elucidate tumoroid workflows and protocols. In addition to democratizing this workflow through the OncoPro Tumoroid Media system, Tumoroid Assay Development Services support outsourced screening and characterization. Customers may also leverage 7 unique OncoPro Tumoroid Cell Lines, representing four different cancer indications including colorectal, lung, endometrial and breast. To improve ease of use, the OncoPro Tumoroid Culture Medium Kit includes a scalable, automation-compatible suspension culture method.

“It is well known that tumor organoids are more predictive of clinical outcomes, adverse events and resistance mechanisms than established 2D cell line counterparts,” said Erik Goka, PhD, vice president of biology at Revere Pharmaceuticals. “The OncoPro Tumoroid Culture Medium Kit allows us to seamlessly integrate tumoroids into our research and drug discovery processes. With the tumoroid media system, we can propagate all our organoid models in the same culture medium system irrespective of the tissue of origin. This media system has been instrumental in allowing us to bring tumor organoids into our lab for everyday use.”

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