Measuring cell clusters without cell separation with 3D imaging

Image Solutions (UK) Ltd has launched the CQ1, a confocal quantitative image cytometer from Japanese company Yokogawa.

The device can accurately quantify the morphological features of live individual cells, clusters such as spheroids, colonies and also tissue sections without the time consuming need to separate cells or remove them from a culture dish.

CQ1 uses a microlens enhanced dual Nipkow disk confocal optical system to obtain accurate 3D images​

Unlike conventional devices, the CQ1 uses a microlens enhanced dual Nipkow disk confocal optical system to obtain accurate 3D images of cell morphological features and measure cell position. This allows scientists to obtain more accurate and reproducible data by maintaining the original biological functions and features of the cells in cell clusters. It is also possible to continue culture experiments for repetitive measurements in order to examine chronological changes – saving time and improving testing efficiency.  A fully customised CQ1 system can also be integrated with external systems for robotic culture dish handling.

The CQ1 is already growing in importance in areas such as regenerative medicine, cell quality evaluation for drug discovery, pharmacology, biopsy evaluation and the study of cancer and other diseases where it is essential to accurately quantify  live cell morphological features without interfering with the cell’s biological functions. It is also becoming very important in other types of cell-related research that involve fluorescence in situ hybridisation (FISH).

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