Burnet Institute and Artes Biotechnology have joined forces to develop a new type of malaria vaccine in a project funded by the PATH Malaria Vaccine Initiative (MVI).
The project will use exciting novel technology developed at Burnet Institute by deputy director, associate professor David Anderson and colleagues. Artes holds the international patent rights and adapted the platform to vaccine production (known as the Metavax platform).
The project will focus on strategies to produce vaccines that can block the transmission of malaria infection from mosquitoes to people.
Purified vaccine antigens (Pfs25 and Pfs230) will be produced as virus-like particles (VLPs, a type of nano-particle) for initial testing in laboratory studies. The VLPs will be taken up by immune cells to prime and prepare the immune system to fight malaria.
Although malaria is one of the world’s leading causes of illness and death there is currently no vaccine approved for use. More than 600,000 people die of malaria each year and it most severely affects young children and pregnant women.
Burnet Institute co-head of the Centre for Biomedical Research, Professor James Beeson says the challenges in developing an effective malaria vaccine are substantial. “One of the challenges for malaria is how to best make vaccines in order to stimulate a strong and effective immune response and boost the immune system to fight malaria infections."
Artes MD Dr Michael Piontek said the strong collaboration is a great opportunity for developing new malaria vaccines. “In this new project, Burnet and Artes will combine their expertise to develop and test a novel approach for producing malaria vaccines. We are excited about the recognition and support provided by MVI for this development work.”
Vaccines that interrupt the transmission of malaria aim to protect whole populations, toward the ultimate goal of malaria eradication.
