A new mycoplasma retentive filter for the biopharmaceutical industry has been launched by Parker domnick hunter. The PROPOR MR speeds up processing of cell culture media, promising the fastest filtration times available without compromising on mycoplasma retention assurance.
Mycoplasma species are common contaminants of cell culture media with the added problem that their small size and deformability gives them the ability to penetrate the 0.2 micron membranes used for sterilizing liquids. For this reason, 0.1 micron filtration has been widely adopted for the filtration of cell culture media; however the higher retention comes at the price of slower flow rates, longer processing times and increased risk of contamination.
“PROPOR MR has been designed in direct response to a market need for faster processing of cell culture media,” said Andrew Kelly, Life Sciences Product Manager at Parker domnick hunter Process Filtration. “Our customers have found that the highly retentive filters used for mycoplasma removal can slow down their process to the point that filtration cannot be achieved within the required time frame. This can significantly increase the risk and potential impact of contamination in the unfiltered cell culture media.”
Parker domnick hunter have developed the PROPOR MR in close collaboration with customers using their actual cell culture media feed streams. The result is a highly retentive filter (typically LRV>10 for Acholeplasma laidlawii) with the fastest processing times for qualified mycoplasma retentive filtration. In addition, an integral prefilter layer maximizes filtration capacity for reduced filter system sizes
The PROPOR MR launch follows the announcement of Parker’s acquisition of Madison based SciLog Inc, provider of automated solutions, and innovative sensor technology and will significantly strengthen Parker domnick hunter’s offering around upstream bioprocessing. PROPOR MR will be available from October 2012.
