In the February 2009 issue of Experimental Biology and Medicine researchers at the National Cheng Kung University, Tainan, Taiwan, have reported a novel phenomenon involving autophagosome formation induced by H. pylori infection and subsequent adoption of these autophagic vesicles by H. pylori for replication in macrophages. The fate of H. pylori is dependent on the strains (isolates) as well as the host macrophages used. Several clinical isolates of H. pylori from Taiwanese patients, but not standard strains, can multiply in the double-layered vesicles of macrophages. The senior author, Dr. Huan-Yao Lei stated that "The autophagy induction by H. pylori is not only found in macrophages, but also in dendritic cells and gastric epithelial cells". This new finding has several implications for the life cycle of H. pylori in the host. H. pylori can be considered as a kind of intracellular microorganism because it can invade host cells to undergo replication within the autophagosome. The bacterium's residence inside infected cells not only increases its resistance to antibiotic treatment, but also avoids neutralization by anti-H. pylori antibodies. In view of the critical role of dendritic cells in presenting H. pylori antigen to initiate the immune response, it is possible that H. pylori-infected dendritic cells induce an inadequate immune response to H. pylori infection that might hinder the clearance of this bacterium. Alternatively, the various immunopathogenesis during the H. pylori-caused diseases might be caused by an unbalanced Th-1 or Th2-mediated response post infection. Finally, the micro-heterogeneity of Taiwanese H. pylori isolates used in this study provides an important hint as to why this microorganism causes so broad a spectrum of diseases. Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine stated "This study also has potential implications for new anti-H. pylori drugs that target the enhancement of autophagy. Dr. Lei and his co-workers have provided an important contribution to our understanding of H. pylori infection."