Blood biomarkers discovered for Alzheimer's disease

PerkinElmer Inc and Predictive Diagnostics Inc, a subsidiary of Large Scale Biology Corporation, have found a series of biomarkers that appear to differ in persons with Alzheimer's Disease compared with persons without cognitive impairment, using a simple blood test.

The collaborative study, initiated by PerkinElmer and David Bennett, M.D., Director of the Rush Alzheimer's Disease Center, Rush University Medical Center (Chicago, Illinois), is among the first study of its kind to describe a potential diagnostic blood test for Alzheimer's disease, although the results will need replication in a separate study.

Mary Lopez, Ph D, Business Leader for Analytical Proteomics at PerkinElmer presented the results at AACC's Oak Ridge Conference in Baltimore, Maryland.

The blood analysis was carried out using PerkinElmer's BioXPRESSION Biomarker platform and Predictive Diagnostic's proprietary BAMF technology to identify patterns of proteins and peptides that distinguish Alzheimer's disease patients from those without clinical signs.

The serum samples used in the study were donated by the Rush Alzheimer's Disease Center.

PerkinElmer's state-of-the-art BioXPRESSION Biomarker discovery and screening platform includes the novel prOTOF 2000 MALDI mass spectrometer, ProXPRESSION carrier protein-based blood biomarker enrichment kits and PDI's BAMF technology.

“This study demonstrates the power of our comprehensive suite of tools and technologies for biomarker discovery and analysis,“ said Peter Coggins, Ph D, president of PerkinElmer Life and Analytical Sciences. “We believe the detection of early disease-related biomarkers is crucial to facilitate the development of diagnostics and drug therapies.“

In numerous collaborative studies, Predictive Diagnostics has demonstrated the capability of its BAMF technology to accurately diagnose cancers such as breast, lung, pancreatic and prostate, as well as multiple sclerosis.

Predictive Diagnostics believes its diagnostic tests will provide better patient outcome through early detection of cancer and other serious diseases and significantly reduce the cost of healthcare associated with treatment of such diseases.

PerkinElmer is a technology leader in innovation in health sciences and industrial sciences. Large Scale Biology Corporation develops biomanufacturing biotherapeutics, diagnostic tests, vaccines and industrial proteins for life science industry markets.

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