A new funding competition has launched to support promising bio-based innovations as they move from laboratory research to commercial production and to boost Scotland’s industrial biotechnology sector
Applications are open for the Industrial Biotechnology Innovation Centre’s (IBioIC) BioProcess Scale-up Accelerator Competition, offering up to £10,000 towards scale-up project costs to help companies and academic teams develop bioprocesses through its FlexBIO facility at Heriot-Watt University in Edinburgh.
Supported by Scottish Government funding, the competition expands on the introduction of Scotland’s first open-access 300-litre fermenter in 2025. Since becoming operational, the facility has helped organisations to test and validate manufacturing processes at commercially relevant scale without the significant capital investment often required for specialist infrastructure.
The accelerator aims to help businesses decrease the risks of bringing new bio-based technologies to market by providing access to FlexBIO’s equipment, technical expertise, and process development capabilities. Projects can range from bench-scale processes through to 300-litre production, supporting companies preparing for manufacturing, customer trials, and future investment.
The initiative addresses the challenge of translating promising research into viable manufacturing processes. While several innovations exhibit strong potential, the cost and complexity of scaling up processes can prevent businesses from progressing to commercialisation.
HydRegen is already benefiting from FlexBIO’s capabilities, a University of Oxford spinout developing technology to replace the heavy metal catalysts traditionally used in chemical manufacturing with cleaner enzymes powered by hydrogen gas.
HydRegen needed a larger batch of enzyme than it could produce in-house to support a demonstration with an industrial manufacturing partner. Working with FlexBIO, HydRegen transferred its established five-litre laboratory process to the 300-litre fermenter, producing material at a 200-litre working volume and generating data confirming the process remained viable at a larger scale.
The project also revealed that HydRegen’s fermentation strategy could be maintained during scale-up, providing the evidence required to support future commercial production and creating a documented, repeatable process for further manufacturing runs.
Neil Renault, director of bioprocessing scale-up at FlexBIO, said, “One year on from the launch of the 300-litre fermenter, we’re already seeing the difference this capability can make for companies looking to move beyond the lab. HydRegen is a great example of how access to infrastructure can provide not only the quantities of material businesses need, but also the process data and confidence required to take the next step towards commercial manufacturing.
“Scaling up isn’t just about making more product. Every process behaves differently as volumes increase, so it’s essential to understand how fermentation, downstream processing and product recovery perform at scale before making further investment. Through the BioProcess Scale-up Accelerator Competition, we want to help more companies reduce risk and advance the development of sustainable bio-based manufacturing in Scotland.”
Dr Matthew Hodges, chief operating officer at HydRegen, said, “Working with IBioIC and the FlexBIO team to scale up our process has been an excellent experience. Access to the facilities and technical expertise has enabled us to successfully demonstrate our technology at a larger scale, giving us greater confidence as we continue towards commercialisation.”
The competition is open to industry and academic-led projects with a credible route to market and plans to secure follow-on investment. Projects must be capable of being completed by the end of March 2027 and demonstrate how they will contribute to Scotland’s bio-based manufacturing sector through business growth, investment, collaborative research and development, or strengthened supply chains. Applications close on 1 September 2026.
