Sino Biological, a specialist in recombinant technology, is launching SuperNuclease Pro. This advanced nuclease has been designed to deliver enhanced nucleic acid removal performance for demanding bioprocessing and molecular diagnostic applications
To help researchers evaluate its performance in their workflows, Sino Biological is also introducing a limited-time trial program offering eligible customers the opportunity to test the solution risk-free.
Nucleic acid removal challenges
Residual nucleic acids are critical impurities that must be effectively removed during the manufacturing of biological products. At the same time, in metagenomic Next-Generation Sequencing (mNGS), the presence of human host DNA in clinical samples compromises pathogen detection sensitivity and inflates sequencing costs.
The efficient degradation of DNA and RNA impurities is vital to improving downstream processing efficiency and supporting compliance with stringent regulatory quality requirements.
SuperNuclease Pro provides enhanced nucleic acid removal, expanding on the foundational SuperNuclease. SuperNuclease Pro delivers improved catalytic activity compared to wild-type Serratia marcescens nuclease across standard cell culture and virus harvest conditions.
For infectious disease diagnostics and high-density processes, SuperNuclease Pro retains exceptional catalytic activity in high-salt environments. This salt-active property enables effective chromatin dissociation and removal of host nucleic acids adhered to viral envelopes. By depleting the host genomic background, SuperNuclease Pro increases the detection sensitivity of low-titer pathogens and reduces overall NGS sequencing costs.
The enzyme also demonstrates broad adaptability across diverse pH ranges, temperatures, and magnesium ion concentrations. Its proven thermostability, validated through 180 days of real-time testing at 37°C, ensures consistent performance throughout extended bioprocessing and diagnostic workflows.
A comprehensive nuclease portfolio
In addition to SuperNuclease Pro, Sino Biological offers a nuclease portfolio designed to address diverse bioprocessing requirements, including GMP-grade SuperNuclease products manufactured in accordance with ISO 13485 and GMP quality management systems, and specialised Salt Active SuperNuclease formulations for high-salt process conditions.
The SuperNuclease Pro free trial
Sino Biological’s limited-time trial program enables qualified customers to evaluate SuperNuclease Pro in their bioprocessing applications prior to full-scale adoption, facilitating faster technology assessment and informed decision-making during process development.
Dr Rob Burgess, chief business officer at Sino Biological US, said, “The launch of SuperNuclease Pro reflects our continued commitment to developing innovative solutions that support the evolving needs of bioprocessing and biologics manufacturing. SuperNuclease Pro provides researchers with a more powerful tool for hard-to-degrade nucleic acid removal. Through our trial program, we are excited to offer customers the opportunity to evaluate its performance firsthand and explore how it can optimise their specific workflows.”
Researchers can visit www.sinobiological.com to learn more about SuperNuclease Pro or click here to request a free sample. This offer is available until October 31 2026.
