Scientific Instruments company Jeol has launched the CRYO ARM 300S and CRYO ARM 200S. These 300kV and 200kV cold field-emission cryo-electron microscopes offer single-particle analysis, cryo-electron tomography and 3DED/Micro ED.
Cryo-EM is central to structural biology and structure-based drug design. However, productivity is often limited by instrument downtime, complex setup and scarcity of expert operators. One particular challenge operators face is that even with modern microscopes, cryo-EM data collection depends on staff expertise. An experienced user must set up each grid one by one, then choosing the right grid squares and holes before imaging can begin.
The microscopes address these constraints and are designed to deliver high-resolution structural data with stability. The CRYO ARM 300S and 200S combine hardware refinements with AI-based automated data acquisition so laboratories can collect more high-quality data per day.
Fringe-free illumination expands the usable imaging area to improve acquisition efficiency, reaching about 1,000 images per hour in practical operation. Specimen exchange capacity increases from four to six cartridges.
Open-source AI-driven software SmartScope multigrid helps the system work more autonomously across multiple grids. Instead of requiring an expert to guide each grid manually, the system can identify grid squares, select holes for imaging and move into data collection with minimal operator input.
As a result of the AI-driven software, more users can run sessions, expert time is freed up and laboratories can collect more data from every microscope run.
