The computational modeling capabilities gave been added to ADME services for enhanced bioavailability profiling
CN Bio, a provider of Organ-on-a-chip (OOC) Systems and solutions that accelerate drug discovery and development workflows, is expanding its Contract Research Services (CRS) with new PhysioMimix computational modelling tools.
This addition has been developed to improve absorption, distribution, metabolism and excretion (ADME) profiling, accelerating drug discovery and development workflows.
The launch reflects the company's new silico tools available to customers, designed to enhance data generation from its selection of predictive vitro tools, discovering insights into key ADME parameters, including human bioavailability, and enabling more confident in vitro to in vivo extrapolation (IVIVE).
CN Bio's computational tools are a combination of insights from microphysiological system (MPS) assays with powerful mathematical models. This complements CN Bios' existing bioavailability assay, which is based on its proprietary dual-organ gut/liver model.
The derived data is compatible with physiologically-based pharmacokinetic (PBPK) frameworks, meaning it can be used to extract additional data from preclinical studies, creating functional predictions of how compounds could interact with human biology.
CN Bio lead scientist Dr Yassen Abbas said: “This year, the FDA made significant changes to phase out animal testing requirements, signalling a clear shift towards the use of more relevant human approaches for preclinical safety and toxicity testing. We are providing the tools to ensure our customers stay ahead of these regulatory changes.”
He added: “The launch of our Bioavailability assay last year was a major step towards improving understanding of the appropriate dose regimens for safe and effective new therapies. Now, by integrating advanced in silico modelling into our offering, we are enhancing this service to bridge the in vitro to in vivo translation gap for drug developers. By working with our expert CRS team, customers have access to dedicated support throughout the entire process.”
