CancerSeq FFPE tissue samples contain mutation and variation data for up to 67 cancer-related genes
One of the notable challenges scientists face when conducting medical research is accurate replicating the intricacies of the human body.
While in-vitro experiments allow for a certain amount of stability in a clinical setting, the removal of components from their normal biological environment may not accurately reflect the genetic diversity of real tissue.
This is problematic in fields such as cancer research, where precisely replicating human physiology is necessary to gain insight into the complex mechanisms driving tumour development.
While traditional in-vitro cancer cell lines or genetically modified cell lines carry one or two mutations, real tumour tissues normally carry more mutations.
Biotechnology company Amsbio’s CancerSeq FFPE tissues offer a way around that challenge.
CancerSeq FFPE tissues are pre-screened tumour tissue samples using targeted next-generation sequencing to identify mutations and mutational hotspots.
"Proven in a wide range of applications, CancerSeq samples are prepared from genomic DNA extracted from authentic tumour tissues, enabling researchers to explore cancer in a more accurate and relevant way,” said Amsbio biorepository business unit manager Phillip Pridham Field.
Prepared from genomic DNA of authentic tumour tissue, CancerSeq, CancerSeq Plus and CancerSeq AMS samples are available as FFPE curls, blocks and slides. The samples contain mutation and variation data for up to 67 cancer-related genes, including BRAF, KRAS, EGFR, ALK and TP53.
To further provide context to the tissue samples, details about the clinical histories and tumour type of the sample can be requested.
This level of context and biological accuracy can assist with the validation of cancer marker mutation related drug candidates, controls for genotyping, companion diagnostic assay development, IHC and in-situ hybridization assays, cellular localization of tissue specific mRNA, protein expression and isolation of DNA and RNA with specific mutation profiles.
