The capsule could enable researchers to move away from less precise faecal samples
A research team at NYU Abu Dhabi has developed a 3D-printed capsule designed to collect microbial samples from the small intestine, helping to study the gut microbiome.
The capsule is called CORAL, or Cellularly Organised Repeating Lattice, and will help to provide a more robust understanding of the interactions between the body and microbes.
“We see CORAL as a transformative tool for unlocking parts of the gut that have long been inaccessible,” said co-author Aashish Jha. “In research, it will allow scientists to study microbial communities in the small intestine with unprecedented detail.”
Traditionally, gut microbiome studies have relied on faecal samples, which miss vital interactions.
Made from inert resin, the capsule has a sponge-like surface which supports diverse microbial life due to its porous structure. The design increases the surface area, enabling the capsule to passively capture microbes.
“The design of the CORAL capsule draws inspiration from the highly complex and self-organized porous architecture observed in marine corals, which themselves are hubs for microbial communities,” the authors wrote in the study published in the journal Device.
Once swallowed, the capsule moves naturally through the body, collects microbial samples and is excreted with the stool. At this point, researchers can retrieve and analyse the capsule.
“In developing CORAL, we prioritised passive design functionalities that simplify manufacturing and minimize failure points,” said co-author Khalil Ramadi. “This robust functionality enhances its clinical utility, and we will be beginning trials in patients soon.”
The capsule is manufactured with a single 3D printing step. The intention is that the simple manufacturing and passive sampling method help researchers to integrate it into larger studies into nutrition, metabolism, disease and immune response.
