£2.7 million to target the nerve centre of the world’s biggest silent killer

High blood pressure is known as the world’s biggest silent killer because most people can’t “feel” their blood pressure going up. To help combat this chronic condition researchers have been awarded £2.7 million to determine possible new treatments.

Light, chemistry, action: a new technique to target skin cancers?

Researchers could starve the tumour of oxygen and nutrients and cause it to disappear

Molecular target aims at aggressive prostate cancer

Researchers have identified a potential target to treat an aggressive type of prostate cancer

Rapid isolation of bacteria or specific target cells

KymaSep system utilises a combination of magnetic and ultrasound forces (acousto-magnetic) to control magnetic beads in a flow-through chamber

New target for antidepressants

University of Michigan scientists have provided the most detailed picture yet of a key receptor in the brain that influences the effectiveness of serotonin-related antidepressants, such as Prozac.

New twist on potential malaria drug target

Researchers seeking to block invasion of healthy red blood cells by malaria parasites have instead succeeded in locking the parasites within infected blood cells, potentially containing the disease.

Nanoparticles target and kill cancer cells

Another weapon in the arsenal against cancer: Nanoparticles that identify, target and kill specific cancer cells while leaving healthy cells alone.

New target for non-Hodgkin's lymphoma

Physician-scientists have discovered a molecular mechanism that may prove to be a powerful target for the treatment of non-Hodgkin's lymphoma.

World will miss 2010 target to stem biodiversity loss

The world will miss its agreed target to stem biodiversity loss by next year, according to experts convening in Cape Town for a landmark conference devoted to biodiversity science.

New target to prevent fatal flu lung complication

A researcher has identified a therapeutic target for acute lung injury resulting in acute respiratory distress syndrome, a highly fatal complication of influenza infection.

Biotechnology: Possible target for Alzheimer's treatment

Researchers have identified a novel receptor in the brain that is extremely sensitive to beta-amyloid peptide and may play a key role in early stages of Alzheimer's disease.

Pharmacology target for breast cancer

New research has uncovered the biological effects of a novel membrane estrogen receptor, a finding that has potential implications for hormonal therapy for breast cancer.

Potential Alzheimer's drug target, pharmacology study

A team of researchers have found laboratory evidence that a cluster of peptides may be the toxic agent in Alzheimer's disease.

Stem cell protein offers a new cancer target

LIN28, a protein abundant in embryonic stem cells, is now shown to be important in cancer, and offers a possible new target for drug development, report researchers.

New treatment target in diseased arteries

Removing a single protein prevents early damage in blood vessels from triggering a later-stage, frequently lethal complication of atherosclerosis, according to recent research.

Understanding a target of quinoline drugs

A recent study shows that quinoline compounds bind to a molecule called S100A9, which is expressed in some white blood cells that are involved in the regulation of immune responses.

New therapeutic target for melanoma identified

A protein called Mcl-1 plays a critical role in melanoma cell resistance to a form of apoptosis called anoikis, according to research published recently.

Successful outsourcing depends on careful selection of target markets

A new report suggests that the successful CROs of tomorrow willbe those that concentrate on the market areas that are witnessing cutting-edge research, focus on high growth categories such as mid-size pharma companies, and which strengthen client relationships through continuous improvement programmes.

Outsourcing drug target proteins and high-throughput screening

Early stages of drug discovery efforts are dependent on the identification and production of high-quality drug target proteins, the rapid screening of compound libraries against these targets, and the generation of preliminary absorption, distribution, metabolism, and excretion (ADME) and toxicology data for the lead compounds. Alex Vodenlich reports.

Antibiotic residues in sausage meat target beneficial bacteria

Antibiotic residues in uncured pepperoni or salami meat are potent enough to weaken helpful bacteria that processors add to acidify the sausage and make it safe for consumption, according to a study published in mBio, the online open-access journal of the American Society for Microbiology.





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