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Genetics: Stem cells lead to breast cancer

Scientists have found that a population of breast cells called luminal progenitor cells are likely to be responsible for breast cancers that develop in women carrying mutations in the gene BRCA1.



BIotechnology: Placental stem cells and lung disease

Researchers have found that stem cells derived from human placenta may ultimately play a role in the treatment of lung diseases, such as pulmonary fibrosis and fibrotic diseases caused by tuberculosis, chemical exposure, radiation or pathogens.



Cell cultures: Maintaining embryonic stem cells

In a new study that could transform embryonic stem cell research, scientists discovered why mouse ES cells can be easily grown in a laboratory while other mammalian ES cells are difficult.



Cell cultures: Stem cell advance from adult mice

Scientists have succeeded for the first time in culturing a clearly defined cell type from the testis of adult mice and converting these cells into pluripotent stem cells.



Stem cell reverses memory decline, biotechnology news

A human growth factor that stimulates blood stem cells to proliferate in the bone marrow reverses memory impairment in mice genetically altered to develop Alzheimer's disease, researchers found.



Automated stem cell high content screening platform

Researchers at I-STEM have used a BioCel 1800 platform to automate high content screening of small molecules for muscular dystrophy therapeutic research.



Stem cell protein offers a new cancer target

LIN28, a protein abundant in embryonic stem cells, is now shown to be important in cancer, and offers a possible new target for drug development, report researchers.



Promising stem cell-gene therapy in genetics

A study has catapulted the field of regenerative medicine significantly forward, proving in principle that a human genetic disease can be cured using a combination of gene therapy and induced pluripotent stem cell technology.



Expanding stem cell promise

Once placed into a patient's body, stem cells intended to treat or cure a disease could end up wreaking havoc simply because they are no longer under the control of the clinician.



Heartbeat drives blood stem cell formation

A beating heart and blood flow are necessary for development of the blood system, which relies on mechanical stresses to cue its formation.



Successful blood stem cell transplants key

Researchers have discovered a molecular key that could help increase the success of blood stem cell transplants, a procedure currently used to treat diseases such as leukaemia and Hodgkin's lymphoma.



Creating safe embryonic-like stem cells

A team of UCSF researchers has for the first time used tiny molecules called microRNAs to help turn adult mouse cells back to their embryonic state.



Making myelin from stem cells

Scientists report the successful generation from human embryonic stem cells of a type of cell that can make myelin, a finding that opens up new possibilities for both basic and clinical research.



Stem cell innovation at risk

Despite great hopes for stem cell therapy, major structural and cultural changes within the NHS are needed if it is to succeed in the UK.



Turning stem cells into muscle

Researchers have created a "switch" that allows mutations or light signals to be turned on in muscle stem cells to monitor muscle regeneration in a living mammal.



Better cultivation – making the most of stem cell research

Stem cell research continues to advance on many levels, particularly in terms of novel cultivation strategies. In the US, however, developments are still being hampered by an ongoing debate over the use of embryonic stem cells in fundamental research. Sean Ottwell reports.



Culturing system boosts stem commercialisation prospects

Last December, Melbourne-based biotechnology company Stem Cell Sciences (SCS) announced that it has opened its new automated stem cell production facility at the Babraham Research Campus in Cambridge, UK.



Notch effect ‘converts’ stem cells into cells of the nervous system

Discovered in 1919, Notch is a protein that can pass a signal from a neighbouring cell and change activity of genes. It causes a mutation in fruit flies that gives them notches on their wings. Such mutants also have many more neural cells than normal flies.



Protein paves the way for correct stem cell differentiation

A single embryonic stem cell can develop into more than 200 specialized cell types that make up our body. This maturation process is called differentiation and is tightly regulated through strict control of gene activity.



Stem cell breakthrough could lead to new bone repair therapies on nanoscale surfaces

Scientists at the University of Southampton have created a new method to generate bone cells which could lead to revolutionary bone repair therapies for people with bone fractures or those who need hip replacement surgery due to osteoporosis and osteoarthritis.



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