New research looks at novel ways to combat drug resistance

University of Southampton biological scientists are leading a major research project aimed at making drugs more effective.

New strategy to fight cancer drug resistance

Scientists at Dana-Farber Cancer Institute have found a way to disable a common protein that often thwarts chemotherapy treatment of several major forms of cancer.

Genetic resistance to rice sheath blight

Agricultural Research Service scientists have identified sources of genetic resistance to sheath blight, a major disease affecting rice production worldwide.

Rust resistance genes added to common beans

New cultivars of common bean developed by scientists could shore up the legume crop's defences against the fungal disease common bean rust. The new cultivars possess two or more genes for resistance to the rust fungi.

Soil studies reveal rise in antibiotic resistance

Antibiotic resistance in the natural environment is rising despite tighter controls over our use of antibiotics in medicine and agriculture, Newcastle University scientists have found.

Genes found linked to breast cancer drug resistance

Researchers have discovered a gene activity signature that predicts a high risk of cancer recurrence in certain breast tumours that have been treated with commonly used chemotherapy drugs.

Paradigm shift needed to combat drug resistance

When people travel, bacteria and other infectious agents travel with them. As about a billion people cross international borders each year, many more billions of the bugs come along for the ride.

Gene that causes resistance to insulin

A breakthrough by an international team of researchers in Canada, France, the UK and Denmark has uncovered a new gene that could lead to better treatment of type 2 diabetes.

Biotechnology: New tumor marker marks resistance

Researchers have discovered a mechanism and a tumour marker for the development of this resistance.

Genetics study explores malaria resistance

Variation in the same gene affects rate of parasite infection in both humans and baboons and may connect important genetic variation to malaria resistance.

Medical potential for tamoxifen resistance

Researchers have uncovered a protein profile that may accurately predict whether a cancer will be tamoxifen resistant.

Weed resistance to glyphosate

Study reviews the environmental history of the weed invasion process to discuss the major drivers and pressures in the context of the changes of the agriculture of Argentina in the last twenty years.

Sugar key to bacterial resistance

The bacteria responsible for chronic infections in cystic fibrosis patients use one of the sugars on the germs' surface to start building a structure that helps the microbes resist efforts to kill them.

Micorbial resistance battle continues

The innate ability of microbes to evade containment and destruction by drugs through rapid reproduction and genetic mutation is exacerbated by the overuse and misuse of existing antimicrobial drugs.

The structure of resistance

A team of scientists from the University Paris Descartes has solved the structure of two proteins that allow bacteria to gain resistance to multiple types of antibiotics.

Nutrients, insulin resistance linked

For some time, scientists suspected the hexosamine pathway - a small side business of the main sugar processing enterprise inside a cell - to be involved in the development of insulin resistance.

Resistance to change continues

There has been a dramatic shift in the drug discovery industry in recent years, with computing power and informatics becoming an integral part of the discovery and development process.

Microbial resistance drives search for new products

The rise and rise of microbial resistance to currently available antibiotics is driving the development of new generation anti-infective products. John Carter reports.

Genotypic analysis of HIV-1 drug resistance mutations

Sven Thamm looks at a fully integrated and complete solution for detecting and reporting HIV-1 resistance to specific anti-retroviral therapy.

Antibiotic resistance: Structures of a multidrug efflux pump in complex with antibiotics

A team at the Institute of Biochemistry of the Goethe University Frankfurt, used X-ray crystallography to solve high resolution structures of the membrane protein AcrB in complex with multiple antibiotics.






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