Genetics: Missing protein leads to brain disorder

Researchers have successfully used protease inhibitors to restore to normal levels a key protein involved in early brain development.

Cancer-causing role for protein

The mainstay immune system protein TRAF6 plays an unexpected, key role activating a cell signaling molecule that in mutant form is associated with cancer growth.

Protein level predicts osteoarthritis

The first study to establish a laboratory marker for the risk of severe osteoarthritis found that vascular cell adhesion molecule 1, was a strong predictor.

Biotechnology: Sticky protein reinforces membranes

A new study shows why muscle membranes don't rupture when healthy people exercise. The findings shed light on a mechanism that appears to protect cells from mechanical stress.

Biotechnology: Human cells secrete cancer-killing protein

Researchers have determined that the tumour-suppressor protein Par-4, initially thought to be active only within cells expressing the Par-4 gene, is in fact secreted by most human and rodent cells and can target large numbers of cancer cells by binding to receptors on the cell surface.

Protein structures revealed at record pace

Scientists have developed a fast and efficient way to determine the structure of proteins, shortening a process that often takes years into a matter of days.

Biotechnology: Flu virus protein damages lung cells

A protein in influenza virus that helps it multiply also damages lung epithelial cells, causing fluid buildup in the lungs, according to new research.

Biotechnology hits with protein snapshot

Researchers have used nuclear magnetic resonance methods to determine the structure of the largest membrane-spanning protein to date.

Protein gel in cell cultures

If proteins bind to a surface, such as on a biochip, the structure can be destroyed and the protein cannot perform its function.

Single protein dimers wavering observed with imaging technology

Researchers have used a very sensitive fluorescence technique to find that a bacterial protein thought to exist in one natural three-dimensional structure, can actually twist itself into a second form.

Biochemistry umasks cancer-causing protein

Research from Tel Aviv University is demonstrating that Ras, one of the first oncogenes discovered, has the power to heal as well as harm.

Biotechnology reveals protein regulates movement of mitochondria in brain cells

Scientists have identified a protein in the brain that plays a key role in the function of mitochondria - the part of the cell that supplies energy, supports cellular activity, and potentially wards off threats from disease.

Stem cell protein offers a new cancer target

LIN28, a protein abundant in embryonic stem cells, is now shown to be important in cancer, and offers a possible new target for drug development, report researchers.

New protein folding method

A new method to induce protein folding by taking the pressure off of proteins is up to 100 times faster than previous methods, and could help guide more accurate computer simulations for how complex proteins fold.

New glucose-regulating protein

Researchers have linked a specialised protein in human muscles to the process that clears glucose out of the bloodstream, shedding light on what goes wrong in type 2 diabetes on a cellular level.

Protein identified as critical to insulating the body's wiring

A new protein identified as critical to insulating the wiring that connects the brain and body could one day be a treatment target for divergent diseases, from rare ones that lower the pain threshold to cancer.

Special protein helps maintain an efficient brain

The instruction manual for maintaining an efficient brain may soon include a section on synaptotagmin-IV (Syt-IV), a protein known to influence learning and memory.

Small molecules might block mutant protein

Molecules that selectively interfere with protein production can stop human cells from making the abnormal molecules that cause Huntington's disease.

DNA protecting protein

A recent work reports that 5FU keeps the DNA-repair enzyme TDG too busy to perform properly in cancer cells, thereby promoting tumour death.

SUMO protein guides chromatin remodeller

Researchers discovered how a protein called SUMO guides an enzyme complex that alters the structure of chromatin to regulate expression of genes.






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