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Notch controls bones

Notch, a protein known to govern the determination of cell differentiation into different kinds of tissues in embryos, plays a critical role in bone formation and strength later in life.



Notch effect ‘converts’ stem cells into cells of the nervous system

Discovered in 1919, Notch is a protein that can pass a signal from a neighbouring cell and change activity of genes. It causes a mutation in fruit flies that gives them notches on their wings. Such mutants also have many more neural cells than normal flies.



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