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Heterocyclic reactive intermediates for drug discovery

During the past 25 years almost every part of the drug discovery process has undergone radical change For instance using robotics and combinatorial techniques chemists can now synthesise single libraries that contain more compounds than existed in the total chemical literature of 1980.



Microdosing trials point the way to smarter drug development

The last thing drug companies need now is an increase in time consuming and expensive clinical trials. But ongoing problems with Cox-2 inhibitors ­ and others ­ mean that regulators are likely to make just such a demand. At the same time, both the regulators and the drug companies want to reduce the number of potential products that fail during clinical development.



Measuring aqueous solubility critical in drug development

The aqueous solubility of a compound is a critical determinant in its success or failure as a drug candidate. Given this, one might anticipate that there is a high throughput, standardised method to measure solubility in the drug discovery and development setting.



Joint initiative aims to accelerate next generation drug discovery

Drug discovery is an extremely lengthy and costly process. On average, it takes new treatments nearly US$1b and 12 years to reach the market ­ and those are just the ones that succeed.



Using ultrasound technology to improve biotech drug economics and safety

In the high-stakes race to bring new biotech drugs to market faster, manufacturers rely on innovative technologies to improve yields and safeguard purity.



Assessing the future of non-invasive nasal drug delivery solutions

Pharmaceutical companies have recognised the advantages of nasal delivery and extended both their product development and the demands on devices to efficiently deliver substances that are potentially more potent and expensive. Chris Halling reports.



Genotypic analysis of HIV-1 drug resistance mutations

Sven Thamm looks at a fully integrated and complete solution for detecting and reporting HIV-1 resistance to specific anti-retroviral therapy.



"aGold standard' in drug production is unnecessary, research claims"

Over-engineering in pharmaceutical companies is pushing up the cost of drugs. But these could be lowered, saving as much as £3 million on a £20 million plant.



workbench automation in drug discovery

Competition in all chemical related markets, ie pharmaceuticals, agrochemicals, fine chemicals etc. has put considerable pressure on the development of new compounds.



Automated recording boosts drug screening capability for researchers

Dr Michael Fejtl reports on the automation of cDNA/mRNA injection and subsequent TEVC recording in Xenopus oocytes plated in 96-well micro-titer plates.



drug discovery brochure features 1000 additions

As the cost of bringing new drugs to the market continues to rise, a afail fast, fail cheap' motto is being pursued through rational drug design to incorporate desirable properties into not only in drugs, but also through the generation of larger numbers of drug-like molecules using combinatorial chemistry methodologies, and the identification and elimination of problematic drugs early.



Partnership agreement over nasal drug delivery

Bespak has successfully reached the next stage of its strategy for nasal drug delivery through the signing of a partnership agreement with Lyfjathr-un Biopharmaceuticals, an Icelandic drug delivery company.



Outsourcing drug target proteins and high-throughput screening

Early stages of drug discovery efforts are dependent on the identification and production of high-quality drug target proteins, the rapid screening of compound libraries against these targets, and the generation of preliminary absorption, distribution, metabolism, and excretion (ADME) and toxicology data for the lead compounds. Alex Vodenlich reports.



drug discovery: a range of solutions

Pharmaceutical companies are currently facing the challenge of significantly increasing the number of NCEs to sustain profitability and investor confidence. This directly impacts on HTS, as this process is at the centre of lead discovery in most major pharmaceutical and biotechnology companies.



Tecan solutions for genomics and drug discovery

Tecan, one of the leaders in laboratory automation solutions, has an in-depth knowledge and understanding of your needs. Its wide product range includes touchscreen-operated microplate readers, multi-label readers, washers and pipetting instruments. Tecan products are user-friendly, flexible and fully modular, so you can start with a small system, then expand and upgrade it as and when you need to. Tecan will customise workstations and complex integrated multi-robot systems to your exact requirements for genomics, drug discovery and other fields.



European drug discovery drive

Pioneering chemists from The University of Nottingham are taking part in the biggest-ever European research programme to speed up the discovery of new drugs.



Prosensa achieves orphan drug status on its entire Duchenne muscular dystrophy portfolio

Prosensa has achieved orphan drug designation in the EU and the US for all of its compounds for the treatment of Duchenne muscular dystrophy (DMD).



Cost of drug development reduced thanks to new technology

De Montfort University has come together with a leading UK-based life sciences commercialisation company, Ithaka Life Sciences Ltd (Ithaka), to market new technology designed to speed up and reduce the cost of the development of new drugs and medicines.



Collaboration helps cut drug development costs

As the cost and complexity of drug development continues to grow, collaboration between manufacturers is becoming an ever more important aspect of the business



Novartis drug Aclasta® study

Novartis has announced that the New England Journal of Medicine (NEJM) published results from a study which found that once-yearly Aclasta® (zoledronic acid 5 mg) significantly reduced the risk of spine fractures by 67% versus placebo over two years in men with osteoporosis (p=0.002)1.



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