Natoli Engineering Company, Inc.

Global Innovator in Tablet Compression Solutions 

For over 50 years, Natoli Engineering Company, Inc. has pushed the boundaries of solid-dose tablet compression production. Serving pharmaceutical, nutraceutical, veterinary, confectionery, and industrial tablet manufacturers worldwide, Natoli delivers precision tooling, high-performance presses, advanced data acquisition software, and critical replacement parts that accelerate production, solve complex tableting challenges, and slash time to market. 

From its St. Charles, Missouri headquarters, Natoli turns advanced engineering, state-of-the-art manufacturing, and hands-on expertise into tablet compression solutions that set the benchmark for the industry. With a track record of innovation, responsiveness, and global reach, Natoli empowers manufacturers to turn ideas into scalable, reliable, and high-output tablet solutions. 

Technical Services 

• Tooling Design 

• Tablet Design 

• Tablet Press Refurbishing 

• Technical Training 

• Formulation Testing and Analysis 

• Metallurgical Analysis

For more information: https://natoli.com/services/ 

Major Products & Services 

Tablet Compression Tooling
Natoli manufactures precision single-tip and multi-tip punches and dies in a wide range of simple to highly complex tablet designs. Tooling is available in more than 15 steel types and 10 specialty coatings to meet demanding production requirements. 

For more information: natoli.com/products/tablet-compression-tooling/ 

Tablet Presses
Natoli offers a range of tablet presses designed for research, formulation development, and production simulation – from single-station benchtop R&D presses to heavy output rotary tablet presses with extended dwell times and high-capacity fill capabilities. 

For more information: natoli.com/products/tablet-presses/ 

Tablet Press Replacement Parts
An extensive inventory of precision replacement parts and turrets is available for most tablet press makes and models, with many components available for same-day shipment. 

For more information: natoli.com/products/tablet-press-replacement-parts/ 

Tablet Compression Accessories
Natoli provides one of the industry’s most comprehensive catalogs of tablet compression accessories, including inspection tools, maintenance equipment, and analytical devices designed to extend tooling life and support consistent tablet production. 

For more information: natoli.com/products/tablet-compression-accessories/ 

Technical Training
Hands-on training programs led by recognized academic and industry experts help tablet manufacturers understand compression science, improve manufacturing processes, and maximize equipment performance. 

For more information: natoli.com/trainings/ 

Tablet and Tooling Design
Natoli provides expert tablet and tooling design services to ensure optimal tablet quality, manufacturability, and long-term product performance. The company also offers TabletCAD, a free web-based tablet design software that enables manufacturers to design tablets to precise specifications. 

For more information: natoli.com/services/ 

Markets Served 

Natoli supports tablet manufacturers across multiple industries including: 

• Pharmaceutical 

• Veterinary 

• Nutritional / Nutraceutical 

• Confectionery 

• Industrial tableting 

Through a global network of distributors and partners, Natoli serves customers throughout North America, South America, Europe, the Middle East, Africa, and the Asia-Pacific region. 

Facilities 

Natoli’s 10-acre campus in St. Charles, Missouri, USA, houses administrative offices, advanced manufacturing operations, tablet press refurbishing facilities, technical training centers, and laboratory and scientific research capabilities supporting tablet compression development and analysis.