The Roche Creatinine Plus enzymatic creatinine assay, for use with cobas or MODULAR Analytics analysers, offers a specific and accurate alternative to the less specific Jaffé method, ensuring clinically more reliable results in the management of patients with chronic kidney disease (CKD)1. Users at GSTS (Guys, St Thomas', Serco) Pathology, London and the University Hospital, Coventry, amongst others, have found that the assay provides a more accurate assessment of renal function.
Supporting a large renal unit, the Biochemistry Department at GSTS Pathology, London performs over 30,000 creatinine tests every month. They have been using the enzymatic Roche Creatinine Plus assay first line for the last three years. "We found the enzymatic test to be more reliable and less prone to interference," explains senior biomedical scientist, Kim Brown. "This has resulted in a reduction in discrepant results, which means that fewer patients are required to be re-bled. Accuracy is extremely important in monitoring pre- and post-transplant patients, since consultants may need to act on a slight change in eGFR. The more accurate Creatinine Plus assay ensures that fewer patients are required to undergo unnecessary invasive procedures."
Similarly, Dr Steve Smith, Service Director of the Clinical Biochemistry and Immunology Department in Coventry has been using the Roche Creatinine Plus assay first line for the last 2 years. Performing around 36,000 creatinine tests every month, he prefers to use a more specific IDMS standardized method. "The Creatinine plus assay enabled us to use the newer MDRD eGFR equation directly since this was generated using the Roche enzymatic assay," comments Dr Smith. "Creatinine Plus is easier to handle on our Roche MODULAR platform than our previous method. Also, being more specific, we get a more accurate picture of a patient's creatinine level, particularly at lower levels where non creatinine chromogens interfere disproportionately with the older Jaffé assay. This is particularly important since we receive a large number of samples from both paediatric and renal patients, for whom there can be significant interference using Jaffé methods."
By providing more accurate results, the Roche Creatinine Plus assay helps to improve patient care and offers a cost effective alternative to less specific methods.
