Novel solid-state NMR probe

Bruker has introduced a new ultra-high speed MAS probe together with a new MAS III controller. The new 111kHz MAS probe, with 0.7mm sample diameter and a sample volume of 500nl, which has been demonstrated up to 1GHz proton frequency, delivers excellent sensitivity and fast spinning frequency for access to new applications in the solid-state NMR analysis of biosolids, as well as in materials science. 

Solid-state NMR is a growing discipline, providing unique structural and dynamics information on various materials and biological solids in their native state, such as membrane-embedded proteins. The additional spectral resolution provided by very fast MAS allows novel detection techniques for structural and functional characterisation of complex molecules. The new 111kHz CP-MAS probe will be useful for large, rigid proteins and those with paramagnetic centers in solid phase, and for the structure elucidation and improvement of advanced materials, such as battery components.

The new 111kHz CPMAS probe extends the Bruker line-up of high speed MAS probes, comprising of 1.9 and 1.3mm probes, now with a 0.7mm MAS system. This gives researchers great flexibility in terms of sample volume and spinning requirements, depending on the sample of interest. A new control unit, the MAS III, ensures stable regulation even at very high rotation rates. The 111kHz MAS probe is avilable for Bruker standard-bore and wide-bore NMR magnets and comes with dedicated tools for convenient filling and handling of the small diameter rotors and caps. 

"The ultra-fast magic angle spinning capabilities of Bruker’s 111kHz MAS probe allows for the direct and high resolution observation of proton resonances from complex biomolecules,” stated Professor Lyndon Emsley from the Ecole Normale Supérieure de Lyon, France. He continued: ”We get double the resolution in protonated samples compared to 60kHz spinning, and we were especially pleased to obtain a 1GHz version of this MAS probe, with which we have measured never-before-seen ultra-high field, ultra-fast MAS data. As such, it is a great new tool in our solid-state NMR arsenal for the structure determination of proteins, a critical need for studying disease mechanisms."

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