Bruker has launched its next-generation of GHz-class NMR technology, with a combination of major method and instrumentation advances that enable even more advanced scientific and translational research in structural biology, drug discovery and the study of macromolecular complexes.
The primary focus of Bruker’s next-generation GHz NMR spectroscopy technology is to enable breakthrough fundamental research in molecular and cell biology on Intrinsically Disordered Proteins (IDPs). In particular, ultra-high field NMR in combination with other experimental and computational methods, has recently been shown to enable more and more detailed studies of the structural ensembles; post-translational modifications; dynamics; multiple interactions; specific binding partners; signalling and regulatory roles; formation of membrane-less cellular organelles; and other important functions of IDPs. Due to the scarcity of understanding of the molecular functions for the vast majority of IDPs, they are sometimes also referred to as the ‘Dark Proteome’.
The latest GHz NMR technology is the result of a confluence of recent break-through scientific discoveries, major technical achievements and key, customer-driven new NMR methods development, including:
• New actively-shielded 1GHz NMR magnets
• Novel high-dimensionality and fast acquisition NMR methods
• 13C and Novel 15N direct detection for large proteins and IDPs
• Advanced parallel NMR with multiple receiver acquisition
• New 3mm TCI CryoProbe for GHz-class indirect experiments
• New triple-gradient 5mm CryoProbes
• Novel single-story Ascend Aeon 900 MHz magnets
• New 1GHz ultra-fast 111 kHz MAS solid-state NMR probe