Analytik reports on ground-breaking work by the Department of Chemistry at the University of Sheffield using a LV-1 microfluidiser to create novel oil-in-water nano emulsions that were subsequently occluded within a calcite crystalline lattice.
Particle Technology is an important discipline that underpins many industrial sectors, including biomedical applications, latex paints and coatings, engine oil additives, viscosity modifiers and emulsion stabilisation. Steve Armes, Professor of Polymer and Colloid Chemistry at the University of Sheffield, is one of the UK's leading experts in particle science and technology, with more than 30 years of research experience in this field. In particular, he designs a wide range of microscopic polymer particles on the nanoscale. He says: "It is well known that oil and water do not mix. Similarly, the incorporation of oil droplets within inorganic crystals is highly counter-intuitive because there is a large difference in surface energy for these two components. Our new occlusion protocol, developed using the high-pressure LV-1 microfluidiser, has enabled either oil-soluble dyes or oil-dispersible hydrophobic nanoparticles to be incorporated for the first time within host crystals. This exciting new innovation has considerable potential to be used as a new environmentally-friendly matrix for the microencapsulation and controlled release of a wide range of actives for various commercial applications. In view of this, we have filed a preliminary patent application to protect the IP associated with our work."
The LV1 microfluidiser is a high shear homogeniser wthat brings excellent processing capabilities to samples as small as 1ml. It has been designed to achieve operating pressures up to 30,000 psi for samples ranging from 1-6ml. Using fixed-geometry interaction chamber technology, it is capable of processing a wide variety of fluids such as oil-in-water emulsions, solids-in-liquid suspensions, and cells, including the most difficult yeasts and plant cells, in as few as one-two passes. The process is repeatable and is guaranteed to scale up to pilot and/or production volumes.