GLP-1R reporter cell line launched

Life-science product and solutions provider Amsbio has launched a Glucagon-Like Peptide 1 Receptor (GLP-1R) reporter cell line.

GLP-1R is known to play a key role in controlling blood sugar levels by enhancing glucose-stimulated insulin secretion. There is therefore considerable interest in harnessing regulation of the GLP-1R mediated signaling pathway as a therapeutic approach to type 2 diabetes which has already resulted in the development of several GLP-1 FDA-approved agonists. In addition, GLP-1R agonists have also been shown to contribute to weight management, decrease the potential for cardiovascular diseases and protect pancreatic beta cells.

This new GLP-1R / CRE Luciferase Reporter HEK293 cell line has been engineered to monitor activation of GLP-1R in cells by measuring luciferase activity, making it useful for cell-based binding assays and screening for human GLP-1R agonists. The functionality of AMSBIO’s new GLP-1R/CRE Luciferase Reporter HEK293 Cell line has been validated in dose-response assays using both peptide and small molecule agonists.

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