CAR-T cell engineering solution optimises cell therapy results

Recent industry trends have underscored the critical role of innovative cell engineering technologies in enhancing the effectiveness and safety of CAR-T cell therapies.

As the demand for personalised and precise therapies continues to grow, biotechnology company Creative Biolabs offers in-vivo CAR T cell engineering solutions that are IVT mRNA-based, circular RNA-based, and viral-based to optimise the cell therapy candidates of global researchers.

IVT mRNA-Based & CircRNA-Based CAR-T Cell Engineering

A scientist said of the work: "We can harness the power of in vitro transcription (IVT) mRNA to engineer CAR-T cells with enhanced functionality and durability.They added: "By transiently expressing these CARs in T cells, we can produce CAR-T cells quickly and efficiently, without the risks associated with genomic integration. This approach not only provides greater flexibility in modifying CAR constructs but also ensures enhanced safety and efficacy."

CircRNAs offer significant advantages like increased stability and translational efficiency, which contribute to prolonged CAR expression, potentially enhancing the therapeutic efficacy of CAR-T cells. Creative Biolabs specialises in managing circular RNA to modulate gene expression and optimise the performance of CAR-T cells. 

Viral-based CAR-T Cell Engineering

Despite the rise of non-viral methods, viral-based CAR-T cell engineering remains a proven and highly effective strategy, according to the company. Creative Biolabs provides viral-based CAR-T cell engineering, employing lentiviral and retroviral vectors for stable integration of CAR genes into T cells. This method ensures durable CAR expression and long-term therapeutic effects. 

"At Creative Biolabs, we are dedicated to pushing the boundaries of cell therapy research and empowering our clients to unlock the full potential of their CAR-T therapy candidates," said the scientist. "Our comprehensive suite of services reflects our commitment to innovation, quality, and scientific excellence."

You can find out more via this link. 


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