Understanding the gene function

The functional genomics revolution started when studies of worms and flies showed the possibility of neutralising the expression of a specific gene by a previously unknown mechanism, called RNA interference or RNAi.

It was found that this mechanism was based on small double-stranded RNA fragments called small interfering RNAs or siRNAs. Later, it was discovered that RNAi also exists in mammalian cells.

Damien Waché, Global Marketing Director for the Proligo Primers & Probes business line, says: "The discovery of the RNAi mechanism is a true revolution because it facilitates better understanding of the roles played by each gene at unprecedented low cost and high speed.“

RNAi could also give rise to new therapeutic applications for viral diseases such as AIDS, hepatitis and even cancers.

Proligo is based in Paris, France. www.proligo.com

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