"With cocaine addiction, addicts don't feel an urge to revolt because there is a strong connection in the brain from the decision-making centre to the pleasure centre, which overwhelms other normal rewards and is why they keep seeking it," Pendyam said. "By using computational models, we're targeting the connection in the brain that latches onto the pleasure centre and the parameters that maintain that process."
Glutamate is the major chemical released in the synaptic connections in the brain; the right amount present determines the activity of those connections. Using the computational model, MU researchers found that in an addict's brain excessive glutamate produced in the pleasure centre makes the brain's mechanisms unable to regulate themselves and creates permanent damage, making cocaine addiction a disease that is more than just a behavioural change.
"Our model showed that the glutamate transporters, a protein present around these connections that remove glutamate, are almost 40 percent less functional after chronic cocaine usage," Mohan said. "This damage is long lasting, and there is no way for the brain to regulate itself. Thus, the brain structure in this context actually changes in cocaine addicts."
Mohan and Pendyam, in collaboration with MU professor Satish Nair, professor of electrical and computer engineering, and Peter Kalivas, professor and chair of the neuroscience department at the Medical University of South Carolina, found that the parameters of the brain that activate the pleasure centre's connections beyond those that have been discovered must undergo alteration in order for addicts to recover. This novel prediction by the computer model was confirmed based on experimental studies done on animal models by Kalivas' laboratory.
"The long-term objective of our research is to find out how some rehabilitative drugs work by devising a model of the fundamental workings of an addict's brain," said Mohan, who will attend Washington University in St. Louis for his postdoctoral fellowship. "Using a systems approach helped us to find key information about the addict's brain that had been missed in the past two decades of cocaine addiction research."
Moham and Pendyam's research has been published in Neuroscience and as a book chapter in New Research on Neuronal Network from Nova Publishers.
