Genetically modified plants to grow vaccines against killer diseases

Genetically modified plants are to be used to grow vaccines for use in the worldwide fight against HIV, tuberculosis, diabetes and rabies thanks to a grant of E12 million from the EU's Sixth Framework Programme.

Pharma-Planta' draws on the expertise and experience of 39 scientists from 11 European countries and South Africa to address significant health problems affecting Europe and the developing world ­ although the primary aim is to provide medicines for poorer countries. In the first international project of its kind, aPharma-Planta' will develop the concept from plant modification through to clinical trials and they expect to begin human trials of the drugs within four years.

“We are addressing the serious issue of global inequality of health,“ says scientific coordinator, Professor Julian Ma from St George's Hospital Medical School in London. “Although the major burden of 21st century disease is in the developing world we have to accept it as a global problem as these are the countries that do not have access to vaccines.

“We know we can use GM technology to force a plant's molecular apparatus to produce a range of medically useful compounds. Already genetic modification of other organisms is being used to produce human insulin and a hepatitis B vaccine. However, plant derived materials used in humans have never been formally addressed within the EU.“

Although the project has not finally decided which plants will be used, the likely candidates are tobacco or maize.

For more information, visit http://fp6uk.ost.gov.uk

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