Purification of Plasmid DNA by polishing and Endotoxin removal

Increasing requirements for higher purity plasmid DNA preparations have driven the development of new chromatography technologies. Victor Bornsztejn reports.

Automation innovations provide twin boost for lab efficiency

Known as Crystal Farm, a new imaging system developed in the USA simplifies and automates protein crystallisation by integrating incubation at chosen temperatures together with optical imaging of the crystal growth plates at pre-scheduled...

Using ultrasound technology to improve biotech drug economics and safety

In the high-stakes race to bring new biotech drugs to market faster, manufacturers rely on innovative technologies to improve yields and safeguard purity.

water for endocrine disrupter analysis

There is concern that certain molecules mimic hormones normally produced within the body and so interfere with their action.

Latest developments in carbon filter technology for recirculating fume cabinets

Robert Monks reports the development of a range of filters with environmentally friendly carbon.

Improved detection limits withX-ray fluorescence spectrometer

Dirk Wissman looks at the monitoring of limits for heavy metaltraces in pharmaceutical products using an energy-dispersiveX-ray fluorescence spectrometer.

Enhancing productivity in preparative separation of enantiomers

The separation of enantiomers by chromatography is a field expanding significantly due to the increasing interest for pure enantiomers in the pharmaceutical industry.

Sequential isolation of plasma proteins aids immunoglobulin yields

The demand for immunoglobulin is high and is predicted to rise. John Curling reports that current goals are to improve yield of immunoglobulin while maintaining product quality.

chromatography data system

Autoscribe Ltd's Varian Galaxie chromatography data system is now available. Galaxie is fully scalable from single chromatograph workstations to global implementations with an easy upgrade path.

The case for contracting analytical physicochemical profiling services

A physicochemical profile is important for predicting drug absorption, disposition and transport. This involves measuringa number of properties which many laboratories are ill-equippedto handle. One solution is to use contract analytical...

Multi-compound LC-MS-MS analyses

Waters Corporation's latest version of QuanOptimise is an enhanced plug-in for the market leading Mass-Informatics platform (MassLynx 4.0).

Affinity chromatography is vital to protein research and development

Because they are derived from living organisms, biological products present a potential source of pathogens. By John M. Curling.

Ultrasonic spectroscopy moves into laboratory for dynamic monitoring

Ultrasonic spectroscopy is all set to become a routine analytical technique in the laboratory. It provides a non-destructive way to measure the properties of materials, using sound waves rather than the more usual electromagnetic waves. As...

Use of hydrogen generators to supply the gas for laboratory use is on the increase

The use of hydrogen generators to supply hydrogen for laboratory use is becoming increasingly widespread.

Sample purification kits for mRNA and protein

Now available from Bio-Nobile Oy is a range of kits for the purification of nucleic acids and proteins, based on BN's magnetic particle separation technology.

launch of

The life sciences are some of the fastest moving industry sectors around today. Technologies, techniques and strategies develop, change and move on at bewildering speed.

Storing and sharing analytical data for maximum commercial benefit

Data-mining, viewing and comparison of data across the organisation are just a few of the issues surrounding the archival of analytical data to facilitate knowledge management. Here, Kevin Smith examines the issues in depth and introduces a...

affiline platform technology

For the design of artificial antibody-like binding proteins ­ the Affilines ­ Scil Proteins is developing the proprietary Affiline Platform Technology.

Imaging crystalline protein grains in 3D using X-ray diffraction

Preparing protein crystals has always been difficult because their growth mechanisms are not well understood. A better insight into these mechanisms is now possible, using a new imaging method based on coherent x-ray diffraction.

broad selectivity and high loading capacity of csps

Over the past 20 years the interest in developing more and more single enantiomeric drugs has grown tremendously since it has been demonstrated that the stereochemistry of such active substances is one of the major factors determining their...




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