Article Archive

Article archive

Plant waste an effective weed control

Interest in organic crop production is increasing around the world. Organics are healthy for consumers while adding environmental benefits and decreasing the amount of synthetic herbicides in foods, soil, and water.

Anti-tumour mechanisms of Scutellaria barbata

Studies indicate that extracts from S. barbata have growth inhibitory effects on a number of human cancers. However, the underlying mechanism of the anti-tumour activity of S. barbata extracts remains unclear.

Survival through self-cannibalisation

A single tumour-suppressing gene is a key to understanding, and perhaps killing, dormant ovarian cancer cells that persist after initial treatment only to reawaken years later, researchers report.

Family history not a factor

A first-degree family history of prostate cancer has no impact on the treatment outcomes of prostate cancer patients treated with brachytherapy and have clinical and pathologic characteristics similar to men with no family history at all.

Toxicity mechanism identified

In cell cultures and animal models of Parkinson's, an accumulation of alpha-synuclein interferes with the cell's recycling of MEF2D, leading to cell death. MEF2D is especially abundant in the brains of people with Parkinson's, the researchers found.

Smokers more likely to have smoke

A new study shows that people who are smokers and have a family history of brain aneurysm appear to be significantly more likely to suffer a stroke from a brain aneurysm themselves.

Pathogenesis of C. jejuni-related disease

Campylobacter jejuni, a food-borne organism contracted from untreated water and meat is one of the leading causes of bacterial diarrhoea worldwide. Researchers investigated whether different strains had different effects.

Predicting anxiety treatment success

A new study reports that high levels of brain activity in an emotional centre called the amygdala reflect patients' hypersensitivity to anticipation of adverse events.

Enabling earlier thyroid cancer treatment

In a study to determine the diagnostic value of molecular imaging in nodal staging of patients with thyroid cancer, researchers were able for the first time to accurately distinguish between cancerous cells in regional lymph nodes and normal residual thyroid tissue directly after surgery.

Making 3D DNA nanotubes

Researchers reveal for the first time the three-dimensional character of DNA nanotubules, rings and spirals, each a few hundred thousandths the diameter of a human hair.

Effective MRSA pre-screening

Pre-operative screening of patients for methicillin-resistant staphylococcus aureus (MRSA) may be an effective way to reduce infection rates following otolaryngic surgeries, according to new research.

The prevalence of gluten-sensitive enteropathy

While gluten sensitive enteropathy was thought to be a rare disease in the past and was believed to be essentially a disease of Europeans, recent screening studies showed that GSE is one of the most frequent genetically based diseases occurred worldwide.

New congenital neutropenia syndrome

A team of scientists has discovered a new syndrome associated with severe congenital neutropenia and identified the genetic cause of the syndrome: mutations in the gene Glucose-6-phosphatase, catalytic subunit 3 (G6PC3).

Genetic variations and cardiovascular diseaes

Researchers from Duke University Medical Center have identified a variation in a particular gene that increases susceptibility to early coronary artery disease.

Antioxidants offer pain relief for patients

Antioxidant supplementation was found to be effective in relieving pain and reducing levels of oxidative stress in patients with chronic pancreatitis, reports a new study in Gastroenterology.

Automated agility boosts use the of electronic document systems

Driven by the demands of the electronic common technical document (eCTD) standard and made easier by hosted offerings, electronic document management is enjoying a renaissance among mid-sized pharma organisations - and for good reason, says Adam Sherlock.

Re-use of technology lies at the heart of business expansion

As western pharma firms look to distant waters to land their next big opportunities, success will depend on efficient re-use of technology, particularly where electronic submissions are concerned. Kate Wilber explains.

A new approach to early drug discovery promises faster results

Andrew Rankin explains how getting a drug candidate into the clinic early can pay dividends.

Human regional absorption studies with Enterion and ivMicrotracer in practice

Enterion is a proprietary electromechanical device used by Pharmaceutical Profiles to deliver a drug under test to specific regions of the GI tract.

Three-dimensional cell culture matrices offer superior results

Every day scientists are one step closer to discovering safer and more effective drugs, and to replacing damaged or diseased human organs and tissues. Simon Nikolay reports.

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