Molecular diagnostics

One of Italy’s leading general hospitals and an important transplant centre, Niguarda Hospital, Milan, performs nearly 25,000 viral load measurements every year, for human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV), hepatitis B virus (HBV) and cytomegalovirus (CMV). As workloads continue to increase, the Molecular Biology Laboratory must meet demands for high quality results and reduced turnaround times without any increase in resources.

Whereas the laboratory’s existing viral load method involves multiple platforms and many manual steps, DxN VERIS consolidates DNA extraction, nucleic acid amplification, quantification and detection for a number of molecular targets (including HIV-1, HCV, HBV and CMV) onto a single automated instrument, requiring far less manual intervention.  Exhibiting comparable performance, the DxN VERIS allowed much faster turnaround of results, with all results being reported within 8 hours of receipt, compared to several days with the existing method.

The DxN VERIS Molecular Diagnostics System is a fully automated sample-to-answer instrument for the quantitative analysis of molecular targets. It integrates sample introduction, nucleic acid extraction, reaction setup, real-time PCR amplification and detection (using TaqMan chemistry), and results interpretation for a fully streamlined workflow. A sample tube is simply loaded onto the DxN VERIS Molecular Diagnostics System and all steps after that are performed automatically, giving molecular diagnostics laboratories the freedom and control to provide the right answers at the right time.

The growing menu of assays for use on the DxN VERIS Molecular Diagnostics System includes the CE-marked VERIS CMV Assay (for the quantitative determination of human Cytomegalovirus (CMV) in plasma), VERIS HBV Assay (for quantitative measurement of Hepatitis B Virus (HBV) in human plasma and serum) and VERIS HCV Assay (for quantitative measurement of Hepatitis C Virus (HCV) in human plasma and VERIS HIV-1 Assay (for quantitative detection of Human Immunodeficiency Virus type 1 (HIV-1) in plasma).

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