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Polysaccharide derivatives coated on a silica matrix have been extensively used as chiral stationary phases (CSPs) for their high selective and loading capacity in enantioseparation by HPLC.

Immobilisation of the polymeric chiral selectors on the support has been considered as a direct approach to confer a universal solvent compatibility to this kind of CSP, thereby broadening the choice of solvents able to be used as mobile phases. In this context, Daicel Chemical Industries Ltd has developed a new generation of CSPs for HPLC using a novel immobilisation technology. CHIRALPAK IA, a 3,5-dimethylphenylcarbamate derivative of amylose, immobilized onto silica, is the first of this series of CSPs to become commercially available.

The immobilisation of the amylose derivative on the silica gel support allows free choice of any miscible solvents to compose the mobile phase and enlarges the application domain of the polysaccharide-derived chiral selector. The column can be used with all ranges of organic miscible solvents, progressing from the traditional mobile phases used with other Daicel columns (mixtures of alkane/alcohol, pure alcohols or acetonitrile) to mobile phases containing ethyl acetate, tetrahydrofurane, methyl tert-butyl ether (MtBE), dichloromethane and chloroform, among others.

The solvent versatility of CHIRALPAK IA and its robustness makes it a powerful tool for chiral method development.

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Chiral Technologies Europe is based in Illkirch, France. www.chiral.fr